Structural Basis of Folding Cooperativity in Model Proteins: Insights from a Microcanonical Perspective
نویسندگان
چکیده
منابع مشابه
Structural basis of folding cooperativity in model proteins: insights from a microcanonical perspective.
Two-state cooperativity is an important characteristic in protein folding. It is defined by a depletion of states that lie energetically between folded and unfolded conformations. There are different ways to test for two-state cooperativity; however, most of these approaches probe indirect proxies of this depletion. Generalized-ensemble computer simulations allow us to unambiguously identify th...
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Proteins function by switching between different well-defined conformations in the native state. In order to reach the native state the protein has to fold. The number of possible conformations is huge, and the existence of folding pathways guiding the proteins between the relevant conformations seems necessary [1]. The existence of pathways has been experimentally established [2–4], but the me...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.03.056